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Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture
Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture
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机译:制备抗生素A-30912混合物以及该抗生素混合物中A,B,C,D,E,F和G因子的方法
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摘要
A process for the preparation of the antibiotic A-30912 mixture which contains the seven factors A, B, C, D, E, F and G is described. This antibiotic mixture is obtained by cultivating an Aspergillus rugulosus which has the deposition number NRRL 8113 under aerobic submerged fermentation conditions in a nutrient medium which contains substances providing assimilable carbohydrates, nitrogen and inorganic salts. As soon as a significant antibiotic activity has formed, the antibiotic mixture is isolated from the fermentation medium. Each of the 7 factors A to G can be isolated individually from this antibiotic A-30912 mixture. The antibiotic A-30912 mixture and the individual factors contained therein have antifungal activity and they can be employed, in particular, as active substances in compositions for controlling fungal diseases of the skin.
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