METHOD FOR PRODUCING THE ANTIBIOTIC MIXTURE A-42355 CONTAINING FACTORS A, B, D AND H OF A-30912 AND THE INDIVIDUAL FACTORS

摘要

A process is disclosed for preparing the A-42355 antibiotic mixture which comprises A-30912 factors A, B, D, and H, and the individual factors, A-30912 factor A, A-30912 factor B, A-30912 factor D and A-30912 factor H, which comprises cultivating the newly isolated Aspergillus nidulans var. roseus NRRL 11440 in a culture medium containing assimilable sources of carbohydrate, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced, separating the antibiotic mixture from the culture medium, and if desired, isolating the individual factors from the antibiotic mixture.