Antitumour medicaments contg. metal complexes - comprising beta-di:ketone complexes of tin, titanium, zirconium or hafnium

摘要

Medicaments contg. complexes of formula (R1(CH2)mCOCR3COR2)xM(X)y (I) are new. M is Sn, Ti, Zr or Hf; R1 is H or phenyl opt. mono- or polysubstd. by F, Cl, Br, NO2, 1-4C alkyl, 1-4C alkoxy or CF3; R2 is Me or R1, but not H; R3 is H or Cl; X is F, Cl or Br, but not F when M is Zr or Hf; m is 1 or 0 but must be 1 when R1 is H; x= 2+n; y= 2-n; n is 0 or can also be 1 when M is Zr or Hf. Cpds. (I) are new, provided that (i) R1 is not H, (ii) R1 is not Ph when M is Sn or Ti; although R2 can be Ph for any M, (iii) X is not Cl when M is Zr and R1 is Ph, (iv) X is not Cl when M is Hf, R1 is Ph and n= 1, and (v) X is not Cl when M is Ti and R1 is p-fluoro-, p-chloro- or p-bromophenyl. Coprecipitates of (I) with hydrophilic polymers are also new. (I) are antitumour agents with comparable cytostatic activity to cis-Pt(NH3)2Cl2 but much lower toxicity.