Mechanisms of Ketone/Imine Hydrogenation Catalyzed by Transition-Metal Complexes

摘要

Alcohols and amines are important in pharmaceutical, perfume, and agrochemical industries. Catalytic asymmetric synthesis is one of the major ways to produce chiral alcohols/amines from prochiral ketones/imines via hydrogenation. Meanwhile, the alcohol/amine dehydrogenation with high hydrogen energy density is paid more and more attention as promising hydrogen-storage media. In this review, we summarize classifications of mechanisms of ketone/imine hydrogenation and alcohol/amine dehydrogenation catalyzed by transition-metal (TM) complexes, the H2activation modes, and the nature of asymmetric ketone/imine hydrogenation (AKH/AIH). This will elaborate our understanding on the nature of the TM-catalyzed ketone/imine hydrogenation and alcohol/amine dehydrogenation reactions.