Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents.

摘要

Compounds having the structural formula: CHEM are disclosed wherein there are 0-4 R groups and R is e.g. hydrogen, lower alkyl, halo-loweralkyl, hydroxy, lower alkoxy, halo, lower alkylthio or lower alkylsulfinyl R1 is e.g. hydrogen or lower alkyl Z is (a) -(CH2)0-n, n being 0-10 (b) -CO(CH2)1-n (c) -(CH2)1-n-CO- or (d) -@@-(CH2)0-n R2 is e.g. hydrogen or lower alkyl R3 is hydrogen, lower alkyl, hydroxy, loveralkoxy or halo and X-Y is eg. -O-CH2- or -S-CH2-. Those compounds have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.