MONOCLONAL ANTIBODIES BRANCHED BY RADIONUCLEID AND THEIR APPLICATION TO VISUALIZATION OF A TUMOR

摘要

THE INVENTION RELATES TO THE FIELD OF PHARMACEUTICAL CHEMISTRY. /P P IT CONCERNS NEW MONOCLONAL ANTIBODIES RELATING TO ANTIGENS ASSOCIATED WITH A TUMOR TO WHICH METALLIC RADIONUCLEIDE IS BOUND, DIRECTLY OR BY MEANS OF A CHELATING AGENT SUCH AS ETHYLENETRIAMINE-PENTA-ACETIC ACID (DTPA) CONJUGATED WITH THE ANTIBODY. /P P IN PARENTERAL ADMINISTRATION TO A PATIENT, THE BRANDED MONOCLONAL ANTIBODY ESTABLISHES IN THE TUMOR AND MAY THEN ESTABLISHED IN THE TUMOR. BE LOCATED BY A PHOTOSCANOGRAPHY DETECTING THE RADIATION EMITTED.