Monoclonal Antibodies APPLICATION FOR IDENTIFICATION OR YAMAGATSKOY Victorian evolutionary lineages of influenza virus type B. STRAIN 4N7 hybrids to produce monoclonal antibodies for certain viruses influenza YAMAGATSKOY branches. STRAIN hybrids / 4H1 For preparation of monoclonal antibodies for certain viruses Influenza Victorian BRANCH

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention discloses using the monoclonal antibodies (MCAs) produced by the hybridomas B/4H1 and 4H7 and directed to variable determinants as a part of influenza B virus proteins. The hybridoma B/4H1 and 4H7 strains are deposited in the Russian Collection of Vertebral Cell Cultures (RKKK P) under Nos. 719 D and 720 D, respectively. The two current influenza B viral evolution lines are identified with using the MCAs B/4H1 and MCAs 4H7 directed to variable determinants of Victorian-type and Yamagata-type influenza B hemagglutinin, respectively.;EFFECT: using the prepared MCA kit enables identifying the newly recovered influenza B viruses Besides, the MCAs under the invention may be used to study the antigenic structure and variability of this agent, to identify them as belonging to a specific evolution line; the MCAs may be also used to construct the diagnostic test systems.;3 cl, 12 dwg, 8 ex