PREPARATION OF POLY(I)-POLY(C)-POLY-L-LYSINE COMPLEX

摘要

PURPOSE:To obtain easily the titled complex, resistant to ribonucleases, and useful as a remedy for viral infectious diseases, etc., by adding a specific amount of an aqueous solution of poly-L-lysine to an aqueous solution of poly(I)-poly(C) (polyinosinic acid-polycytidylic acid), adjusting the pH, and solubilizing insoluble substances in the mixture solution. CONSTITUTION:(B) An aqueous solution of poly-L-lysine is added to (A) an aqueous solution of poly(I)-poly(C) (polyinosinic acid-polycytidylic acid) to give 1: 0.35 or above weight ratio between the components (A) and (B), and both components are mixed. The pH of the resultant mixture solution is then adjusted to =8 with an aqueous solution of sodium dihydrogenphosphate, and the mixture solution is stirred to solubilize insoluble substances in the mixture solution. Thus, a transparent poly(I)-poly(C)-poly-L-lysine complex is obtained. The resultant complex is preserved as an aqueous solution or a hypotonic solution and preferably diluted with a physiologically saline solution or isotonic vehicle for use.