首页> 外国专利> 1-(1-(3,6-DIHALOGENO-2-(2,3-EPOXYPROPOXY)PHENYL)-VINYL)-1H- IMIDAZOLE AND ITS SALT

1-(1-(3,6-DIHALOGENO-2-(2,3-EPOXYPROPOXY)PHENYL)-VINYL)-1H- IMIDAZOLE AND ITS SALT

机译:1-(1-(1-(3,6-二卤代戊-2-(2,3-环氧丙烷)苯基)-乙烯基)-1H-咪唑及其盐

摘要

NEW MATERIAL:The compound of formula I (X and Y are halogen) and its salt. EXAMPLE:1-{1-[3,6-Dichloro-2-(2,3-epoxypropoxy)phenyl]vinyl}-1H-imidaz ole. USE:A synthetic intermediate of the amino-alcohol of formula II (R is lower alkyl) having antiarrhythmic effect. The reaction of the compound of formula I with the alkylamine of formula RNH2 gives the pharmaceutical compound of formula II. PROCESS:The compound of formula I can be prepared by reacting 2-hydroxy- acetophenone of formula III with an imidazolizing agent (e.g. 1-1H-imidazole sulphenyl chloride), and reacting the resultant vinyl imidazole of formula IV with an epihalohydrin in the presence of a base (e.g. NaOH) at room temperature or under heating.
机译:新材料:式I的化合物(X和Y为卤素)及其盐。实施例:1- {1- [3,6-二氯-2-(2,3-环氧丙氧基)苯基]乙烯基} -1H-咪唑。用途:具有抗心律不齐作用的式Ⅱ氨基醇(R为低级烷基)的合成中间体。式I化合物与式RNH 2的烷基胺的反应得到式II的药物化合物。工艺:可以通过使式III的2-羟基苯乙酮与咪唑化剂(例如1-1H-咪唑亚磺酰氯)反应,并使所得的式IV的乙烯基咪唑与表卤代醇反应来制备式I的化合物在室温或加热条件下制备碱(例如NaOH)。

著录项

  • 公开/公告号JPS5993077A

    专利类型

  • 公开/公告日1984-05-29

    原文格式PDF

  • 申请/专利权人 SHIONOGI SEIYAKU KK;

    申请/专利号JP19820203483

  • 发明设计人 OGATA HIDE;

    申请日1982-11-18

  • 分类号C07D405/12;

  • 国家 JP

  • 入库时间 2022-08-22 09:29:30

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