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Method for preparing a Solid Unit dosage form, therapeutically Active Pattern, with regular Release and prolonged to be administered
Method for preparing a Solid Unit dosage form, therapeutically Active Pattern, with regular Release and prolonged to be administered
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机译:定期释放并延长给药时间的固体单位剂型的治疗活性形式的制备方法
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摘要
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.
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