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A METHOD FOR THE PREPARATION OF A SOLID UNIT THERAPEUTICALLY ACTIVE POSOLOGICAL FORM, WITH REGULAR AND PROLONGED RELEASE GUIDELINE ON BEING ADMINISTERED.
A METHOD FOR THE PREPARATION OF A SOLID UNIT THERAPEUTICALLY ACTIVE POSOLOGICAL FORM, WITH REGULAR AND PROLONGED RELEASE GUIDELINE ON BEING ADMINISTERED.
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机译:一种制备固体的具有治疗活性的形态学方法的方法,该方法以规范的和延长的释药指南为准。
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摘要
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.
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