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Levorotatory N-substituted acylmorphinans useful as analgesic agents
Levorotatory N-substituted acylmorphinans useful as analgesic agents
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机译:左旋N-取代的酰基吗啡喃可用作镇痛药
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摘要
Levorotatory N-substituted acylmorphinans of the formula IMAGE I wherein R1 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl-lower alkyl, cyano-lower alkyl, aryl-lower alkyl, or 5- or 6-membered heterocyclic-lower alkyl, and one of R2 or R3 is hydrogen and the other of R2 or R3 is alkanoyl of 2 to 7 carbon atoms, aroyl, trifluoromethylcarbonyl or IMAGE wherein R is hydrogen or lower alkyl and n is an integer of 0 to 6, and salts thereof with pharmaceutically acceptable acid addition salts, are described. The compounds of formula I are useful as analgesic agents.
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机译:式 I的左旋N-取代的酰基吗啡喃,其中R 1是氢,低级烷基,低级烯基,环烷基-低级烷基,氰基-低级烷基,芳基-低级烷基或5-或6-元杂环-低级烷基, R 2或R 3中的一个为氢,另一个R 2或R 3为碳数为2至7的烷酰基,芳酰基,三氟甲基羰基或,其中R为氢或低级烷基,n为0至6的整数,以及盐描述了其与药学上可接受的酸加成盐。式I化合物可用作止痛剂。
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