Effect of Levorotatory Amlodipine on carotid atherosclerosis, inflammatory response and endothelial function in hypertensive patients

摘要

Objective: To investigate the effect of Levorotatory Amlodipine on carotid atherosclerosis, inflammatory response and endothelial function in hypertensive patients. Methods: A total of 180 cases of patients with essential hypertension were randomly divided into control group and observation group. In the control group, life intervention was treated, and the observation group was treated with l-amlodipine in addition to life intervention, and continued treatment for 5 months. The oxidative stress index, inflammatory factor, vascular endothelial function index and β2-microglobulin and PDGF-BB levels were compared before and after treatment. Results: There were no significant differences in the levels of oxidative stress indicators MDA, SOD, inflammatory factors TNF- , hs-CRP, vascular endothelial function markers ET-1, NO,β2-microglobulin and PDGF-BB before treatment. The levels of MDA, TNF-α, hs-CRP, ET-1, β2-microglobulin and PDGF-BB in the two groups were significantly lower than those in the same group before treatment. The levels of SOD and NO were significantly higher than those in the same group. The levels of TNF-α and hs-CRP in the observation group were (26.64±2.79) ng/L and (8.29±3.15) mg/L, respectively, which were significantly lower than those in the control group. The level of ET-1 in the observation group was (50.31±21.72) ng/L significantly lower than that in the control group, and the level of NO was (78.27±16.14)μmol/L was significantly higher than that in the control group. The observation group β2-microglobulin and PDGF-BB were (2.29±0.23) mg/L and (19.06±1.91) ng/mL, which were significantly lower than the control group. Conclusion: L-amlodipine in the treatment of hypertension can effectively reduce the level of oxidative stress, inhibit the release of inflammatory factors and significantly improve vascular endothelial function, which has certain clinical value.