SYNERGISTIC ANTIHYPERTENSIVE COMPOSITIONS CONTAINING A RENAL DOPAMINERGIC DERIVATIVE OF 1-HYDROXYPHENYL-7,8-DIHYDROXY BENZAZEPINE COMPOUND AND A DIURETIC AGENT

摘要

Compositions useful for treating hypertension contain a renal dopaminergic agent for example a 6,9-optionally substituted-7,8-dihydroxy-1-(hydroxyphenyl)- 2,3,4,5-tetrahydro-1H-3-benzazepine or a salt and/or O-alkanoyl ester thereof, combined with a diuretic agent. Especially useful are compositions containing as active ingredients 6-chloro-7,8-dihydroxy- 1-(4-hydroxyphenyl)- 2,3,4,5-tetrahydro-1H- 3-benzazepine or a pharmaceutically acceptable salt thereof combined with triamterene, hydrochlorothiazide or ticrynafen. The medicinal compositions are administered internally but most readily orally.