1,3-THIAZOLIDINE-4-YL-CARBOXYLIC ACID DERIVATIVES OF PENICILLANIC ACID AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I IMAGE (I) wherein: R represents hydrogen, (C1-4)alkyl, aralkyl, phenyl, phenyl substituted by a halogen atom or a methoxy group, formyl, acyl, trimethylsilyl; R' represents hydrogen, a pharmaceutically acceptable inorganic or organic cation, (C1-4)alkyl, 2,2,2-trichloroethyl, acetonyl, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl; R' may also represent a radical capable of providing metabolic activation in vivo selected from acetoxymethyl, pivaloyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula IMAGE or a group of formula IMAGE in which R'' stands for (C1-4)alkyl, (C5-6)cycloalkyl or aryl; n may be zero or 1. The compounds possess antibacterial utility against microbial infections in man, animals and plants.