首页> 外国专利> Vaccine against diseases caused by reo viruses, combined vaccine with Newcastle disease virus, process for preparing them and reo virus strain used for their preparation

Vaccine against diseases caused by reo viruses, combined vaccine with Newcastle disease virus, process for preparing them and reo virus strain used for their preparation

机译:针对两种病毒引起的疾病的疫苗,新城疫病毒与新疫苗的结合疫苗,其制备方法和用于制备它们的呼肠孤病毒株

摘要

Vaccines derived from avian reo virus to combat aber- tions of the skeleton such as rachitis-like symptoms, osteoperose c.q. femur degeneration, diarrhoea and grown inhibition, a process for their preparation, combined, inact.- vated vaccines, ready for administration and active against at least Newcastle disease and disease symptomes caused by reo virus and process for the preparation of such vaccine, ai e disclosed.;The combined vaccine is prepared by addition of a Newcastle disease virus (NDV) containing liquid, obtained by cultivation of a NDV, followed by inactivation of this liquid and optionally homogenizing it, together with a reo virus-containing liquid, obtained by cultivation of a rea virus, followed by inactivation of this liquid and optionally homogenizing it, to an oily phase containing as essential components at least one of the components selected from the group consisting of light paraffinic mineral oils, plant oils and pafthenic mineral oils and one or more emulsifiers, such as non-ionic surface-active compound derived from alkylene oxide and/or hexahydric alcohols and/or higher natural fatty acids such as esters or ester-ethers, optionally followed by homogenizing and or addition of a preservative.;Also a reo virus strain LZ 671, deposited with the collection D'lnstitut Pasteur. Paris under no. I-092 is disclosed.
机译:源自禽呼肠孤病毒的疫苗,用于抵抗骨骼畸形,例如棘毛炎样症状,骨质疏松症。股骨变性,腹泻和生长抑制,其制备过程,联合的,无效的疫苗,易于给药,对至少由呼肠孤病毒引起的新城疫和疾病症状的疫苗具有活性,并且该疫苗的制备方法通过添加含有新城疫病毒(NDV)的液体来制备组合疫苗,该液体是通过培养NDV而获得的,然后使该液体失活,并可选地将其与含有呼肠孤病毒的液体一起匀浆,该液体通过培养rea病毒,然后使该液体失活并任选使其均质化为油相,该油相包含至少一种选自轻链烷烃矿物油,植物油和磷灰石矿物油的成分作为基本成分,或更多种乳化剂,例如由环氧烷和/或六元醇和/或高级天然脂肪衍生的非离子型表面活性化合物诸如酯或酯醚之类的酸,任选地随后均质化和/或添加防腐剂。也有呼肠孤病毒菌株LZ 671,保藏在D'Institut Pasteur馆藏中。巴黎下号公开了I-092。

著录项

  • 公开/公告号EP0013449B1

    专利类型

  • 公开/公告日1984-02-08

    原文格式PDF

  • 申请/专利权人 GIST-BROCADES N.V.;

    申请/专利号EP19790200774

  • 发明设计人 KRASSELT MANFRED MAX;APONTOWEIL PETER;

    申请日1979-12-17

  • 分类号A61K39/15;A61K39/295;C12N7/00;

  • 国家 EP

  • 入库时间 2022-08-22 09:00:41

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