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4-TERT.-BUTOXY-PHENYL-GLYCINE NITRILE, AND PROCESS FOR THE PREPARATION OF D-(-)- AND L-(+)-4-HYDROXY-PHENYL GLYCINE
4-TERT.-BUTOXY-PHENYL-GLYCINE NITRILE, AND PROCESS FOR THE PREPARATION OF D-(-)- AND L-(+)-4-HYDROXY-PHENYL GLYCINE
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机译:4-叔丁基苯酚甘氨酸腈及其制备D-(-)-和L-(+)-4-羟基苯丙氨酸的方法
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摘要
4-Tert.-butoxyphenylglycinonitrile (I) IMAGE I and a process for the preparation of D-(-)-4-hydroxyphenylglycine (IIa) and L-(+)-4-hydroxyphenylglycine (IIb) IMAGE wherein compound I is reacted in a conventional manner, in alcoholic solution and in the presence of a carbonyl compound, with about the equimolar amount of L-(+)-tartaric acid or D-(-)-tartaric acid and the D-(-)-I-L-(+)-tartrate or L-(+)-I-D-(-)-tartrate thereby obtained in crystalline form is converted to IIa or IIb respectively in aqueous acid solution at 20 DEG -110 DEG C. by splitting off the L-(+)-tartaric acid or D-(-)-tartaric acid, hydrolyzing the nitrile group and hydrolytically splitting off the tert.-butyl group.
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