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A process for the preparation of New Antibiotics, especially derived from UNWTO, modified in C - 23.

机译:一种新抗生素的制备方法,特别是从世贸组织衍生的新抗生素,经C-23修饰。

摘要

Process for the preparation of New Antibiotics, especially derived from UNWTO modified C - 23.Consists of: (a) submit a compound of formula (i), where r is an azido Reduction reaction with triphenylphosphine to a temperature of between 0 and 100jc, to form a compound of formula (i), where r is - NH2; and b) optionally, acilar amino derivative to form a compound of formula (i) Where R IS - NHR, R is an acyl Group; R IS h, alcanoilo C 1 to 5, Benzoyl and others; R IS h,Alcanoilo C 1 to 5, phenylacetylene and others; R IS h, alcanoilo C 1 to 5 and others; and R IS h, alkyl Cyclohexyl C 1 to 6, and others.
机译:制备新抗生素的方法,尤其是从世贸组织经修饰的C-23衍生的新抗生素,包括:(a)提交式(i)的化合物,其中r为与三苯膦的叠氮基还原反应,温度为0至100jc,形成式(i)的化合物,其中r为-NH 2; b)任选地,氨基芳基衍生物形成式(i)的化合物,其中R是-NHR,R是酰基; R IS h,Alcanoilo C 1至5,苯甲酰基等; R IS h,Alcanoilo C 1至5,苯乙炔等; R IS h,阿尔卡诺伊洛C 1至5等; R 1为烷基,环己基C 1至6等。

著录项

  • 公开/公告号ES8504841A1

    专利类型

  • 公开/公告日1985-07-16

    原文格式PDF

  • 申请/专利权人 ELI LILLY AND COMPANY;

    申请/专利号ES19830524197

  • 发明设计人

    申请日1983-07-18

  • 分类号C07H17/04;A61K31/70;

  • 国家 ES

  • 入库时间 2022-08-22 08:06:04

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