PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS

摘要

Pharmaceutical composition having a high degree of anthelmintic activity comprising I) levamisole of formula (2), and IIa) a subsituted benzimidazole carbamates of formula (3), wherein R1 represents a 5- or 6-membered heterocyclic ring or a radical -NHCO2R2, wherein R2 represents alkyl; R3 represents alkyl, or a radical -NHCO2R2 or a radical -XR4, wherein X represents O, CO, S, SO, SO2, -SO2-O- or -O-SO2 and R4 represents a hydrocarbon group or aryl substituted by alkoxy, halogen or alkyl groups which in turn are substituted by at least one halogen atom, with the proviso that when R1 is in the 5-position and R1 represents -NHCO2CH3 and X represents CO, R4 does not represent phenyl and with the further proviso that at least one of R1 and R3 must represent the radical -NHCO2 alkyl, (IIb) pro-drugs therefor or (IIc) non-toxic acid addition salts of said substituted benzimidazole carbamates or pro-drugs. The invention also relates to a dosage unit of such a composition and a method for treating helminthiasis in animals by administering an effective amount of such composition.