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Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid

机译:制备无糖,无淀粉,喷雾干燥的含90%抗坏血酸的维生素C粉末的方法

摘要

The subject invention relates to a vitamin C powder prepared by (a) spray drying an aqueous slurry of ascorbic acid and binder in the presence of an absorbent in amounts such that the resulting powder will contain at least 90 percent by weight of ascorbic acid, no more than 9 percent by weight of binder, from 0.2 to 2 percent by weight of absorbent; and blending from 0.2 to 5 percent by weight of a lubricant into the powder prepared by step (a). Preferably microcrystalline cellulose and mixtures of microcrystalline cellulose and hydroxypropylmethycellulose are used as the binder.PPThe resulting sugar and starch free vitamin C powder prepared by this process will be free flowing, have an ascorbic acid content of at least 90 percent by weight, be color stable under use conditions, will contain a lubricant, and is directly compressible into tablets which have acceptable hardness, friability, color stability, and disintegration times.
机译:本发明涉及一种维生素C粉末,其通过以下方式制备:(a)在吸收剂的存在下将抗坏血酸和粘合剂的水性浆液喷雾干燥,使所得粉末含有至少90重量%的抗坏血酸,而不含粘合剂的重量百分比大于9%,吸收剂的百分比百分比为0.2至2%;将0.2-5重量%的润滑剂掺入步骤(a)制备的粉末中。优选地,微晶纤维素以及微晶纤维素和羟丙基甲基纤维素的混合物用作粘合剂。通过该方法制备的所得无糖和淀粉的维生素C粉末将自由流动,抗坏血酸含量为至少90%。按重量计,在使用条件下颜色稳定,将包含润滑剂,并且可直接压制成具有可接受的硬度,脆性,颜色稳定性和崩解时间的片剂。

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