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SUGAR AND STARCH FREE SPRAY-DRIED VITAMIN C POWDER CONTAINING 90 PERCENT ASCORBIC ACID

机译:含90%抗坏血酸的糖和淀粉免费喷雾干燥的维生素C粉

摘要

ABSTRACT OF THE DISCLOSURE:A vitamin C powder is prepared by firstly spraydrying an aqueous slurry of ascorbic acid and binder in thepresence of an absorbent. The amounts are selected so thatthe resulting powder contains at least 90 percent by weightof ascorbic acid, no more than 9 percent by weight of binderand from 0.2 to 2 percent by weight of absorbent. Then from0.2 to 5 percent by weight of a lubricant may be blendedinto the powder prepared by the spray drying step.Preferably microcrystalline celulose and mixtures ofmicrocrystalline cellulose and hydroxypropylmethycelluloseare used as the binder. The sugar and starch free vitamin Cpowder prepared by this process is free flowing, has anascorbic acid content of at least 90 percent by weight, iscolour stable under use conditions, contains a lubricant andis directly compressible into tablets which have acceptablehardness, friability, color stability, and disintegrationtimes.
机译:披露摘要:首先喷雾制备维生素C粉干燥抗坏血酸和粘合剂的水性浆料吸收剂的存在。选择金额,以便所得粉末至少含有90%(重量)抗坏血酸,不超过粘合剂的9重量%和0.2至2重量%的吸收剂。然后从可以混合0.2至5%的润滑剂制成通过喷雾干燥步骤制备的粉末。优选地,微晶纤维素及其混合物微晶纤维素和羟丙基甲基纤维素用作粘合剂。不含糖和淀粉的维生素C通过此过程制备的粉末是自由流动的,具有至少90%的抗坏血酸含量为在使用条件下颜色稳定,含有润滑剂和可直接压制成可接受的片剂硬度,脆性,颜色稳定性和崩解性次。

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