In the vaccine production which includes the grain which possesses with surface antigen and polymerization human serum arubuminreseputa - of the B die hepatitis virus the useful constituent, the aforementioned way manner null in order to obtain the animal cell, and these cells which can produce

摘要

Composition useful for producing vaccines containing particles having immunogenic properties characteristic of antigen HBsAg, said particles being more particularly characterized in that they also contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a gene of viral hepatitis B, said DNA sequence being placed under direct control of a promoter enabling the efficient transcription of said sequence in human or animal cells transformable by said vector.