Amino di:methylamino-ethyl benzo-isoquinoline-di:one - prepd. by redn. of 2-(di:methylamino-ethyl)-5-nitro benzo-isoquinoline 1,3-di:one with hydrazine with palladium- carbon catalyst

摘要

2-Amino 2-(2-dimethylamina ethyl) benzo-(d,e)iso-quinoline 1,3-dione of formula (I) is prepd. industrially by redn. of 2-(dimethylamino ethyl) 5-nitro benzo-(d,e) isoquinoline 1,3-dione with hydrazine in presence of a catalyst of 10% Pd on carbon and n a suitable solvent such as methanol. Addn. of 80% hydrazine hydrate is carried out slowly over 30 mins., the mixt. reflux for 3.5h with agitation and filtered hot. After standing overnight at ambient temp., the prod. is filtered off and re-crystallised.