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New pseudo-polysaccharide cpds. with glucosidase inhibiting activity
New pseudo-polysaccharide cpds. with glucosidase inhibiting activity
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机译:新的假多糖cpds。具有葡糖苷酶抑制活性
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摘要
Pseudooligosaccharides of formula (I) and their physiologically acceptable acid salts are new, where l = 1 or 2; m = 1-3; n = 1-20. Also new is the microorganism Streptomyces galbus subspecies FH 1716 (DSM 3007). - (I) are made by fermenting appropriate Streptomycetes, esp. DSM 3007, esp. under submerged, aerobic conditions. Fermentation is pref. at 20-35 deg.C and pH 6-9, typically for 1-10 days. (I) are present in both the mycelium and, mostly in the culture filtrate. They can be recovered by usual methods, esp. first adsorption onto a polystyrene resin, then elution with buffers or aq. organic solvents. Individual (I) can be sepd. by e.g. ion-exchange or molecular-sieve chromatography.
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机译:式(I)的假低聚糖及其生理上可接受的酸盐是新的,其中l = 1或2; n = 1。 m = 1-3; n = 1-20。同样新的是微生物链球菌亚种FH 1716(DSM 3007)。 (I)通过发酵合适的链霉菌,特别是通过发酵而制得。 DSM 3007,尤其是在水下有氧条件下。发酵是首选。在20-35℃和pH 6-9下,通常持续1-10天。 (I)既存在于菌丝体中,又主要存在于培养滤液中。它们可以通过常规方法恢复,尤其是。首先吸附到聚苯乙烯树脂上,然后用缓冲液或水溶液洗脱。有机溶剂。个人(I)可以分隔。通过例如离子交换或分子筛色谱。
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