Method for preparing noroximorfona from Morphy - na

摘要

Method for preparing noroximorfona from Morphine.Comprising: (a) treat morphine with a haloformato Ester of formula (X - C (FO) OR1, between 40jc and 120jc to obtain, (ii); (b) (ii) oxidation with Chromium TRIOXIDE and 25jc between 0J, for (iii); (c) to acilar (iii) with an Acid anhydride of Formula 2 (R2) or a formula (r2x acyl Halide ), to produce between 100 and 105jc, (iv); (d) to oxidize (iv) with aromatic carboxylic peracido,Between 10jc and 100jc to form Hydrogenated) (V), and (V) in the presence of PD / C, RD / C and 25J and to get 80jc, (VI) and (f) Hydrolyze (VI) with methanesulfonic acid, in the presence of so4h28n and between 90j and 100jc, to obtain (I). Where R1 and R2 alquenilo and other alkyl; R2 and x Hal. Used as Analgesics.