CONSTANT RELEASE RATE SOLID ORAL DOSAGE FORMULATIONS OF DRUGS HAVING A PK.SUB.A7-10 AND AN AQUEOUS SOLUBILITY OF 15-100 G/ML WATER

摘要

ABSTRACTA constant order release rate solid oral dosageformulation of a drug having a pka 7-10 and a watersolubility of from 15-100g/ml water, said formulationcomprising: a therapeutically effective amount of a saiddrug; from about 0.5 to 6.0 weight percent of an acid-retardant or hydrophobic cellulose derivative; from about 2.5to 35 weight percent of a hydrogenated vegetable oil: fromabout 1 to 20 weight percent of an acrylic acid polymer; fromabout 0.5 to 4.0 weight percent of fumed silicon dioxide andfrom about 0.4 to 300 percent of a lubricant.