Novel derivatives of the acid amino 3 - 2 - oxo azetidine 1 - sulfamic, their process of preparation, their application as medicinal products and products needed for their preparation #

摘要

An azetidine of formula (I): IMAGE or a salt thereof, in which R represents a hydrogen atom or a linear or branched, alkyl, alkenyl, or alkynyl radical having at most 12 carbon atoms, which radical is optionally substituted; R1 represents a radical -(CH2)n-X; in which n represents an integer from 1 to 4; and X represents a halogen atom; a cyano radical; a radical O-R'1 in which R'1 represents a hydrogen atom or an alkyl radical; or X represents a radical S-R''1 in which R''1 represents a hydrogen atom, an alkyl radical or a heterocyclic radical; or X represents a radical IMAGE in which R' and R'' are the same or different and each represents a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms, or R' and R'' together with the nitrogen atom to which they are attached form a heterocyclic radical; or X represents an azido, a thiocyanato or an isothiocyanato radical; and the wavy line indicates that the compound is in its cis or transform or in the form of a cis-trans mixture; the oxime group in the compound being in the syn form, and the compound being in the racemic or an optically active form, is a new compound. The azetidine and its pharmaceutically acceptable salts are medicaments particularly antibiotics.