Substitutedpyrimido 6,1-a!isoquinolin-4-ones,pyrimido 6,1- a!benzozepin-4- ones and pyrimido 6,1-a!benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension

摘要

Pyrimidone derivatives of the formula ##STR1## wherein n is the integer 1 or 0; A.sup.1 and A.sup.2 are independently methylene or mono- lower alkyl or di-lower alkyl methylene; X is methylene, mono-lower alkyl or di-lower alkyl methylene, nitrogen or lower alkyl nitrogen; R is hydrogen or lower alkyl; and Y and Z taken together are the group ═ NR. sup.5, or R and Z taken together form a N--C--bond and Y is a group -- N(H) R.sup.5 ; R.sup.1, R.sup.2 and R.sup.3 are hydrogen, lower alkyl or lower alkoxy, or R.sup.1 and R.sup.2 or R.sup.2 and R.sup.3 taken together are methylenedioxy or ethylenedioxy; R.sup.4 is hydrogen or lower-alkyl; R. sup.5 is phenyl or phenyl substituted by one or more of R. sup.6, R.sup.7 and R.sup.8 which, independently, are chlorine, fluorine, bromine, lower- alkyl or lower-alkoxy; and provided that at least one of the methylene groups A.sup.1 and A.sup.2 is mono-lower alkyl or di-lower alkyl methylene, when R.sup.4 is hydrogen and n is 0,PP and physiologically compatible salts thereof which have blood platelet aggregation-inhibiting activity or have activity on the circulatory system, are described.PPThe compounds of formula I are obtained starting from corresponding chlorinated or brominated pyrimidone derivatives.