PYRIMIDO(6,1-A)ISOQUINOLIN-4-ONE AND PYRIMIDO(6,1-A)-BENZAZEPIN-4-ONE DERIVATIVES,THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

RAN 4044/62AbstractPyrimidone derivatives of the formula Iwherein n is the number 1 or 0,X, A1 and A2 are optionally mono-lower alkylatedor di-lower alkylated methylene,or X is optionally lower alkylated nitrogen,R is hydrogen or lower-alkyl and Y andZ together are a group =NR5,or R and Z together are a N-C-bond and Yis a group -N(H)R5,R1, R2 and R3 are hydrogen, lower-alkyl orlower-alkoxy,or two of R1, R2 and R3 on adjacent carbonatoms are methylenedioxy or ethylenedioxy,R4 is hydrogen or lower-alkyl,R5 is phenyl optionally substituted by R6,R7 and R8,and R6, R7 and R8 are chlorine, fluorine,bromine, lower-alkyl or lower-alkoxy,with the proviso that at least one of themethylene groups A1 and A2 is mono-lower alkylatedox di-lower alkylated when R4 is hydrogen and nis the number 0,and physiologically compatible salts thereof have bloodplatelet aggregation-inhibiting activity or have activityon the circulatory system.These compounds are obtained starting from corres-ponding chlorinated or brominated pyrimidone derivatives.