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PROCESS FOR PRODUCTION OF NEW DERIVATIVES OF QUINOLIN, IZOQUINOLIN AND QUINASOLINE AND MEDICAL PREPARATIVES CONTAINING OF THESE NEW COMPOUNDS
PROCESS FOR PRODUCTION OF NEW DERIVATIVES OF QUINOLIN, IZOQUINOLIN AND QUINASOLINE AND MEDICAL PREPARATIVES CONTAINING OF THESE NEW COMPOUNDS
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机译:喹诺林,异喹诺林和喹啉新衍生物的生产工艺以及包含这些新化合物的药物制剂
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摘要
Amides of formula: IMAGE I in which A is IMAGE V and W are H, halogen, alkyl (1-3C), alkoxy (1-3C), NO2 or CF3, Z is bound in the ortho or para position with respect to B and is phenyl, optionally substituted, thienyl or pyridyl, the chain X-(CH2)n-(CHR)m-CO-NR1R2 is bound in the ortho or para position with respect to B, R is H or alkyl (1-3C), R1 and R2 are alkyl (1-6C), cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, alkenyl (3-6C), R1 and R2 can also form, with the nitrogen atom to which they are attached, a pyrrolidine, piperidine, morpholine or thiomorpholine ring, X is CH-R3, N-R4, SO, SO2, O or S, R3 is H, alkyl (1-3C), R4 is alkyl (1-3C) m=0 or 1 and n=0, 1 or 2, provided that, if X is SO, SO2 or N-R4, the sum m+n is equal to at least 1, that, when A and B are N and Z is in the para position with respect to B, X cannot denote the group CH-R3 and that when A is CH, B is N, Z is in the ortho position with respect to B, X is an oxygen atom, and R is a hydrogen atom, the sum m+n is other than 1, and excluding 2-phenyl-4-quinolyl N,N-dimethylcarbamate, have useful pharmacological activity, e.g. as anxiolytics, anticonvulsants and antiangina agents.
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