N-(BENZAZEPIN-3-YL)-AND N-(BENZODIAZEPIN-3-YL)-ALKYLENE-N-INDOL-3-YL-ALKYLENE-AMINE DERIVATIVES,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

This invention relates to novel indole derivatives of the formula IMAGE (I) wherein A represents a -CH2-CH2-, -CH=CH-, IMAGE group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a -CO-CO- or IMAGE group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group, G represents an alkylene group, R1 represents a hydrogen, chlorine, or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxyl, alkoxy, or phenylalkoxy group, R2 represents a hydrogen, chlorine, or bromine atom or a hydroxyl, alkoxy, phenylalkoxy, or alkyl group or R1 and R2 together represent an alkylenedioxy group, R3 represents a hydrogen, chlorine, or bromine atom or an alkyl group, R4 represents a hydrogen atom or an alkyl or phenylalkyl group, R5 represents a hydrogen, fluorine, chlorine, or bromine atom or an alkyl, hydroxyl, alkoxy, or phenylalkoxy group, R6 represents a hydrogen atom or an alkoxy group, and R7 represents a hydrogen atom or an alkenyl, alkyl or phenylalkyl group, and the acid additional salts thereof. These compounds, which may be obtained by use of known methods, have valuable pharmacological properties, particularly a heart rate-lowering activity.