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Method of preparing pharmaceutical compositions with controlled biphasic release profile of active substance from a drug core and from the pores of a membrane coating surrounding the core.
Method of preparing pharmaceutical compositions with controlled biphasic release profile of active substance from a drug core and from the pores of a membrane coating surrounding the core.
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机译:从药物核心和围绕核心的膜包衣孔制备具有受控物质双相释放活性成分的药物组合物的方法。
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摘要
The present invention concerns a novel pharmaceutical preparation having a biphasic release pattern. The preparation comprises a tablet core containing a drug. The tablet is coated with a coating essentially consisting of a film-forming water-insoluble polymer having fine water soluble particles randomly distributed therein. The fine particles include a drug active substance, which is the same as the drug in the core. The drug active substance in the particles may also be different from the one in the tablet core.
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