Method of preparing Pharmaceutical compositions with biphasic controlled release Profile of active substance from a drug Core and a Coating from the Pores of Membrane surrounding the nucleus.

摘要

Method for preparing Pharmaceutical compositions with biphasic Release Profile.Comprising: (a) Dissolving a film-forming Polymer selected from the group consisting of Cellulose Derivatives, Acrylic Polymer, Vinyl Polymer, which is insoluble in water and Gastrointestinal Fluids in an organic Solvent such as acetone dissolved particles; (b) 0.5 to 100 mm Material Creator of pores that includes an active substance as a drug in therapeutically effective amount, which may be the same or different from the tablet; (c) to prepare a suspension with a) and b) to form a Coating Fluid; and (d) apply the Fluid Coating or Na Tablet drug for 10 minutes to 10 hours at a temperature of 5 to 80jc,And let it dry for a coated tablet. Usable for Manufacturing medicines that provide two active substances in combination.