Process for the continuous enzymatic production of gluconic acid or its derivatives and sorbitol and/or mannitol

摘要

1. A method of continuous enzymatic production of gluconic acid and/or derivatives thereof and i. sorbitol or ii. mannitol or iii. sorbitol and mannitol from disaccharides containing glucose and/or fructose, characterised in that the disaccharide starting substrate is split into the corresponding monosaccharides by specific glycosidases in a reaction step occurring simultaneously or before the redox process, and if required the glucose/fructose ratio is adjusted to about 1:1 by enzymatic isomerization (likewise simultaneous or previous) by glucose-converting xylose isomerase or by chemical isomerization, and an aqueous solution of glucose and/or fructose or an aqueous solution of a disaccharide containing glucose and/or fructose is continuously supplied to a reactor containing glucose dehydrogenase and i. sorbitol dehydrogenase or ii. mannitol dehydrogenase or iii. polyol dehydrogenase and, if required, additional dehydrogenases, isomerases or specific glycosidases and an additional redox system, and an aqueous solution containing the products formed is continuously withdrawn from the reactor.