PHOSPHORUS-CONTAINING BIPHENYL DERIVATIVES AND THEIR USE IN ASYMMETRIC HYDROGENATION AND ENATIOSELECTIVE HYDROGEN SHIFTS

摘要

Novel chiral phosphorus compounds of the general formula IMAGE I wherein R signifies substituted or unsubstituted phenyl, R1 and R2, which can be the same or different, signify hydrogen, lower alkyl, lower alkoxy, di-lower alkylamino or protected hydroxymethyl or R1 and R2 together signify the group IMAGE +TR IMAGE in which m represents a number 3 to 5, R4 represents lower alkyl, substituted or unsubstituted phenyl or benzyl and R5 represents lower alkyl or both R5's together represent lower alkylene, R3 signifies methyl, lower alkoxy, di-lower alkylamino or fluorine and n signifies the number 0, 1, 2 or 3, are described. The compounds of formula I are useful in the form of complexes with a metal of Group VIII as catalysts for asymmetric hydrogenations and enantioselective hydrogen displacements in prochiral allylic systems.