首页>
外国专利>
Medicament for reducing nephrotoxicity caused by positively charged agents such as aminoglycosides and methods of use thereof
Medicament for reducing nephrotoxicity caused by positively charged agents such as aminoglycosides and methods of use thereof
展开▼
机译:减少由带正电荷的药物如氨基糖苷类引起的肾毒性的药物及其使用方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Novel medicaments and methods of use thereof are disclosed for reducing in a human or an animal nephrotoxic effects associated with positively charged molecules or agents. The positively charged molecules or agents may be endogenous or exogenous to the human or animal. Examples of endogenous positively charged molecules or agents include proteins or myoglobin, whereas exogenous positively charged molecules and agents may be pharmaceuticals, such as those derived from the aminoglycoside antibiotic family. The medicament comprises a positively charged (cationic) substance which is preferably substantially inert and substantially secreted by the proximal tubules of the kidney. An example of a positively charged (cationic) substance that is substantially inert is amprolium. In addition, the medicament may include a pharmaceutical, such as an aminoglycoside antibiotic for treating bacterial infection.
展开▼