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Laevorotatory antipode of moprolol as an antihypertensive
Laevorotatory antipode of moprolol as an antihypertensive
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机译:莫普洛尔的催乳剂对高血压
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摘要
This invention relates to a process for the separation of moprolol into its two optical antipodes, substantially characterized by the fact of salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+) moprolol; treating the resultant mother liquors which contain in solution the L(+) glutamate salt of (-)moprolol with a base so as to separate the laevorotatory isomer of crystalline moprolol, which finally undergoes a purification. The invention also relates to a pharmaceutical composition containing said laevorotatoryisomer of moprolol.
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