The relative electrical charge of a cell or organ unit can be affected by capacitive connection between the interstitial fluid in an organ area and a differently charged capacitor. An electrode introduced into this fluid and connected to earth, which is a reference for determining the tissue potential activates the relative voltage over the cell membranes and the voltage of the organ in relation to others. This effect occurs slowly with earthing but can be rendered more effective by introduction of a voltage source between earth and the tissue. This can give either a positive or negative voltage in relation to earth. The capacitive charge movement between terminals gives rise to a variation in the conditions for ion pumping over the cell membrances. Thus, it is possible to affect the ion transport by voltage blocking and thus even affect the voltage gradients between the electrode tissue ambience and the voltage in the organ outside the affected tissue.
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