A process for the preparation of dihidrapiridinas antisquemicos useful as antihypertensive agents and anti-.

摘要

1,4-dihydropyridine derivatives of the formula (I): CHEM and pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxy-ethyl; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; X is a group of the formula: CHEM wherein R3 is H, het, -(CH2)n-het, -NH-het, -NH-(CH2)n-het, -O-het, -O-(CH2)n-het, -(CH2)n-OH, -NR6R7, -(CH2)nNR6R7 or -NH- -(CH2)pNR6R7; R4 is H, C1-C4 alkyl, -(CH2)pNR6R7, -(CH2)p-OH or -(CH2)n-het; and R5 is H, C1-C4 alkyl or phenyl; wherein R6 and R7 are each independently H or C1-C4 alkyl or the two groups R6 and R7 are taken together with the nitrogen atom to which they are attached to form a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(C1-C4 alkyl)piperazinyl group; n is 1-4 and p is 2-4; with the proviso that when R4 is H or C1-C4 alkyl, R3 is not H or -NR6R7. These compounds are useful as anti-ischaemic and anti-hypertensive agents.