ASYMETICL 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTERS HAVING MOIETIES FACILITATING SEPARATION AND USEFUL AS INTERMEDIATES FOR PREPARING THERAPEUTICALLY ACTIVE ANALOGUES

摘要

ABSTRACTNew compounds useful as therapeutical agents and useful as inter-mediates for the preparation of other therapeutically active di--hydropyridines, which new compounds are of the formula Iwherein R1 in one or two (the same or different) substituents onthe phenyl ring selected from the group consisting of NO2, Cl andlower alkyl; R is -CH3, -CHO or , wherein R11 andR12 are same or different, straight or optionally branchedlower alkyl or both together are part of 5-7 membered ring, provid-ed that when one of R is -CH3 the other is -CHO or wherein R11 and R12 have the meaning givenabove; processes for the preparation of said compounds; pharmaceu-tical preparations containing said compounds, a method for theirtherapeutical use and new processes using said compounds as inter-mediates for the preparation of therapeutically active dihydro--pyridines.