Diastereoisomer A of 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid 3- (1-Benzyl-pyrrolidin-3-yl) ester 5-methyl ester, the optical isomer hoejredrejende thereof, processes for preparing the compounds and pharmaceutical compositions containing them

摘要

This invention provides new medicaments having coronary vasodilatory activity of superior degree and durability, these being diastereoisomer A of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(benzylpyrrolidin-3-yl) ester 5-methyl ester, the melting point of the hydrochloride of this diastereoisomer A being 200 to 206 DEG C (decomp); the dextro-rotatory isomer of this diastereoisomer A; and pharmaceutically acceptable acid addition salts of these compounds. The medicament compounds of the invention can be separated from admixture with other isomers by various methods including chromatography and fractional crystallisation.