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GLUTARIMIDE ANTIANXIETY AND ANTIHYPERTENSIVE AGENTS
GLUTARIMIDE ANTIANXIETY AND ANTIHYPERTENSIVE AGENTS
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机译:谷丙酰胺抗焦虑药和抗高血压药
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ABSTRACTGlutarimide derivatives of the formula which areuseful antihypertensive and antianxiety agentswherein R1 and R2 each independently represent hydrogen, a 1to 4 carbon alkyl, a 1 to 4 carbon alkoxy, halogen, nitro,hydroxy, S03H, S02NH2, and then R1 and R2 are takentogether, form a fused phenyl group at the 1,2- or 3,4-positions, with the proviso that when R1 and R2 areidentical they each represent a hydrogen, a 1 to 4 carbonalkyl, a 1 to 4 carbon alkoxy, hydroxy or a halogen group;A and B independently represent an oxo, a thio or an iminogroup having the formula -N(R6)- wherein the R6 group ishydrogen or a 1 to 4 carbon alkyl group; R3 is a hydrogen,a 1 to 4 carbon alkyl or hydroxyethyl group; n is aninteger of from 2 to 5; and R4 and R5 represent methylgroups or when taken together form a cyclopentane orcyclohexane ring; its enantiomers; and the pharmaceuticallyacceptable acid addition salts thereof.
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