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DNA PROBES FOR IDENTIFYING MUTATIONS IN THE HUMAN PHENYLALANINE HYDROXYLASE GENE
DNA PROBES FOR IDENTIFYING MUTATIONS IN THE HUMAN PHENYLALANINE HYDROXYLASE GENE
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机译:鉴定人类苯丙氨酸羟化酶基因突变的DNA探针
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摘要
Disclosed is a method for detection of the mutation in phenylalanine hydroxylase genes. This method can be used for the detection of PKU affected, PKU heterozygotes and normals. Also disclosed are oligonucleotides synthesized to detect the first mutations identified in the human phenylalanine hydroxylase gene. The synthesized probes have base pair mismatches with genomic DNA to facilitate the diagnosis of normal and mutant phenylalanine hydroxylase genes. A simple method for detection of the genetic trait, PKU, without obtaining a previous family history of PKU is provided.
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