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Pulmonarsurfactantproteiner, their preparation and use, its constituent polypeptides and DNA segments and rekombinantnucleinsyremolekyle expressing them
Pulmonarsurfactantproteiner, their preparation and use, its constituent polypeptides and DNA segments and rekombinantnucleinsyremolekyle expressing them
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机译:肺表面活性蛋白蛋白,其制备和用途,其组成多肽和DNA片段以及表达它们的重组核素
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摘要
Polypeptides consisting essentially of from about 10 to about 60 amino acid residues having alternating hydrophobic and hydrophilic amino acid residue regions are useful as pulmonary surfactants when admixed with a pharmaceutically acceptable phospholipid. The polypeptides may be represented by the formula (ZaUb)cZd, wherein: Z is a hydrophilic amino acid residue independently selected from R, D, E and K; U is a hydrophobic amino acid residue independently selected from V, I, L, C, Y and F; a has an average value of about 1 to about 5; b has an average value of about 3 to about 20; c is 1 to 10; and d is 0 to 3.y of
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