substituted quinoline and quinoline derivatives and method for manufacture thereof, intermediates for use in their production and pharmaceutical agents containing the derivatives

摘要

Compounds of structure (I) CHEM in which R1 is hydrogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6-alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, phenyl, phenylC1-6alkyl, the phenyl groups being optionally substituted; R2 is hydrogen, C1-6alkyl, C1-6alkoxy, amino, C1-6-alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C1-6alkanoyl or trifluoromethyl; m is 1, 2 or 3; p is 0 to 4; R3 is hydroxyC1-6alkyl, polyhydroxyC1-6alkyl, C1-6alkoxy1-6alkyl, hydroxyC1-6alkoxy, polyhydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy or hydroxyC1-6alkoxyC1-6alkoxy; and R4 is hydrogen, hydroxy, C1-6alkyl, or C1-6alkoxy, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.