Process for the preparation of novel, 5-position substituted -car bolin-3-carboxylic acid derivatives with valuable pharmacological properties.

摘要

Substituted beta -carbolines of the formula I …IMAGE… in which… R3 denotes the 5-oxadiazolyl radical …IMAGE… where R' has the meaning C1-3-alkyl and C3-C6-alkyl and… the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl,… R4 denotes hydrogen, methyl, ethyl and methoxymethyl and… RA denotes the aryl radical …IMAGE… and the aralkyl radical …IMAGE… where X has the meaning C1-12-alkyl, it being possible for the alkyl radical to be straight-chain, branched, saturated or unsaturated and for a CH2 group to be substituted by a carbonyl group, and where R''' has the meaning fluorine, chlorine, bromine or iodine, C1-3-alkyl, C1-3-alkoxy, C1-5-acyloxy, phenyl, C2-5-alkylenedioxy, trifluoromethyl, nitrilo, nitro or an amino group -NRIVRV where… RIV and RV have the meaning hydrogen, C1-3-alkyl, C1-5-acyl or phenyl, it being possible for RIV and RV to be identical or different and to form a 3-6-membered hetero ring system together with the amino nitrogen atom,… it being possible for the substituent R''' to occur once or more on the aryl radical in an identical or different manner, and a process for their preparation are described. …??The compounds have an action on the central nervous system and are thus suitable as psychopharmaceuticals.