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The process for the preparation of pharmacologically valuable saturated or unsaturated -phenyl- (3-pyridyl) -carboxylic acid derivatives and their tetrazolyl analogues
The process for the preparation of pharmacologically valuable saturated or unsaturated -phenyl- (3-pyridyl) -carboxylic acid derivatives and their tetrazolyl analogues
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机译:制备具有药理价值的饱和或不饱和-苯基-(3-吡啶基)-羧酸衍生物及其四唑基类似物的方法
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摘要
The present invention relates to novel pyridyl derivatives of the general formula IMAGE in which R6 is a pyridine group which is optionally substituted in the 3- or 4-position by an alkyl group, and X, Y, A, n and R3 to R6, R7 and R8 are as defined in Claim 1, their enantiomers, and their cis- and trans-isomers, if R4 and R5 together represent a carbon-carbon bond, which derivatives have useful properties. The compounds of the above general formula I, in which R7 represents a cyano group and Y represents an alkoxy, phenoxy, alkylthio of phenylthio group, are intermediates and the other compounds have useful pharmacological properties, in particular antithrombotic effects, and at the same time the novel compounds are additionally thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSI) and thus also inhibit the effects mediated by thromboxane. Further, these compounds also have an effect on PGE2 production in the lung and on PGD2, PGE2 and PGF2 alpha production in human platelets.
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