PROCESS FOR PRODUCTION OF CRYSTALL-MIXTURES CONTAINING INSULINE OR DERIVATIVES OF INSULINE AND MEDICAL PREPARATIVES CONTAINING SUCH CRYSTALLS

摘要

Mixed crystals composed of (a) unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and (b) least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin and Arg-B31 human insulin and/or Arg2-(B31-32) human insulin. These mixed crystals are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.