PROCESS FOR PRODUCING INSULINE, INSULINE-ANALOGUES AND INSULINE DERIVATIVES

摘要

A method for making insulin and certain derivatives thereof from a compound of the formula (I) wherein Ac is an N-protective group removable by proton solvolysis, X is hydrogen or an S-protective group, and W is -(CH2)-n where n is an integer from zero to four and one -CH2- member thereof may be replaced by -S- or -SO2-, which comprises solvolyzing the Ac groups and dehydrogenating the -SX groups to S-S bonds to form a compound of the formula (II) and then eliminating the BRIDGE BY Edman degradation. Compounds of the formula II.