首页>
外国专利>
4-alkyl-1,4-dihydropyridine compounds which antagonize the action of platelet activating factor (PAF)
4-alkyl-1,4-dihydropyridine compounds which antagonize the action of platelet activating factor (PAF)
展开▼
机译:拮抗血小板活化因子(PAF)作用的4-烷基-1,4-二氢吡啶化合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
4-alkyl-1,4-dihyropyridines, with PAF-antagonist activity, of formula (I) wherein R is saturated C1-C4, R min is saturated C1-C6 alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R2 is saturated C1-C4 or phenyl, the compound wherein R is methyl, R min is ethyl and R2 is phenyl remain excluded, are described. The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor. CHEM a
展开▼